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Optimization of Glycosylation Profile of Recombinant Interferon-Beta-1a Produced by СНО Cells in Wave-Induced Motion Bioreactor
Optimization of Glycosylation Profile of Recombinant Interferon-Beta-1a Produced by СНО Cells in Wave-Induced Motion BioreactorАвтор: N.V. Lobanova, A.A. Nurbakov, V.I. Aksenova, A.A. Chupyrkina, N.A. Shamonov, A.A. Klishin, L.V. Ermolina, E.N. Sautkina, R.A. Khamitov, and Yu.A. Seryogin Страница: 55-66
Optimization of Glycosylation Profile of Recombinant Interferon-Beta-1a Produced by СНО Cells in Wave-Induced Motion Bioreactor Biotekhnologiya, 2013, N 2, P. 55-66 UDC 602.6:612 Section: “Biologicals Technology”
N.V. Lobanova 1, *, A.A. Nurbakov 1, V.I. Aksenova 1, A.A. Chupyrkina 1, N.A. Shamonov 1, A.A. Klishin 1, L.V. Ermolina 2, E.N. Sautkina 2, R.A. Khamitov 2, and Yu.A. Seryogin 1 1 Limited Liability Company “Pharmapark”, 117246, Moscow Russia 2 The State Research Institute for Genetics and Selection of Industrial Microorganisms, 117545, Moscow Russia e-mail: natalya.lobanova@bioprocess.ru
Culturing conditions for a recombinant interferon-beta-1а producing cell line based on Chinese hamster ovary cells (CHO) and cumate expression system have been optimized. The addition of
Key words: bioreactor, CHO cells, cultivation, interferon-beta-1a, glycosylation, optimization.
The full English version of the article was published in “Biotechnology in Russia”, 2013, Issue 2, pp. 55-66 as N.V. Lobanova, A.A. Nurbakov, V.I. Aksenova, A.A. Chupyrkina, N.A. Shamonov, A.A. Klishin, L.V. Ermolina, E.N. Sautkina, R.A. Khamitov, and Yu.A. Seryogin “Optimization of Glycosylation Profile of Recombinant Interferon-Beta-1a Produced by СНО Cells in Wave-Induced Motion Bioreactor”. It is contained at the Russian Scientific Electron Library website: http://elibrary.ru/item.asp?id=21818759
10.04.2015, 1907 просмотров. |
ContactsPostal address: Tel: +7 (495) 315-08-01 Email: editor@genetika.ru |