Freeze-drying of Biopreparations in Dual-Chamber Syringes

Автор: M.A. Zhuchenko, M.A. Pashkova, and O.V. Potapenko

Страница: 79-84

Freeze-drying of Biopreparations in Dual-Chamber Syringes

Biotekhnologiya, 2015, N 4, P. 79-84

UDC 66.049.6

Section:  “Processes and Equipment”

M.A. Zhuchenko ^{1, *},  M.A. Pashkova ²,  and  O.V. Potapenko ¹

¹  The Closed Stock Venture FARMAPARK,  117246, Moscow Russia

²  The Closed Stock Venture Khimfarmresurs,  117312, Moscow Russia

e-mail:  axiflipper@gmail.com

A possibility of biologicals freeze-drying in pre-filled syringes depending on syringe type and various conditions of heat-transfer has been investigated. The effect of preliminary freezing on foaming and lyophilisate quality was studied. An approbation of aluminium blocks destined to the homogenous heat-transfer within a freeze-dried series was performed. A high-quality product that falls within the existing specifications was oblained.

Key words:  biopharmaceuticals,  desorption,  freeze-drying,  pre-filled syringes,  pre-freezing,  sublimation.

06.11.2015, 1524 просмотра.