|
Russian Journal of Biotechnology
→
Articles archive
Archive 2015
→
N 4
→
Grounds for the Propionibacterium freudenreichii RVS-4-irf Strain Clinical Trials as a Nutrient Component (nourishment)
Grounds for the Propionibacterium freudenreichii RVS-4-irf Strain Clinical Trials as a Nutrient Component (nourishment)Автор: E.P. Ryzhkova, V.V. Serebrov, I.V. Danilova, and T.V. Bykovchenko Страница: 70-78
Grounds for the Propionibacterium freudenreichii RVS-4-irf Strain Clinical Trials as a Nutrient Component (nourishment) Biotekhnologiya, 2015, N 4, P. 70-78 UDC 579.676 Section: “Utilization of Biopreparations”
E.P. Ryzhkova 1, *, V.V. Serebrov 2, I.V. Danilova 1, *, and T.V. Bykovchenko 3 1 The Dept. of Microbiology, Lomonosov Moscow State University (MGU), 119991, Moscow, Russia 2 The State Research Center for Biotechnology Vector, 630559, Kol'tsovo. Novosibirskaya oblast Russia 3 The Research Institute for Bakng Industry, (NIIKP), 107553, Moscow Russia e-mail: epr322@mail.ru
The strain of Propionibacterium freudenreichii RVS-4-irf (VKPM B-9654; International GenBank AC: no. (EU418709) isolated in 1988 from Swiss-type cheese manifests some probiotic-significant features having appropriate effects on animal organism (quails). Its cells demonstrate rather high level of survival under aggressive conditions of a model system of GIT, about 60% log CFU/ml. Unlike lacticacid bacteria, P. freudenreichii has low growth requirements, which is accompanied by the production of multiple nutraceuticals: vitamins of the B group, bifidogenic factor, essential amino acids and others. In view of the above said and the previously shown pronounced antioxidant activity, the investigated strain is of interest as a transient probiotic with the putative in vitro activity. The P. freudenreichii strain is capable of producing a high level of vitamin B12 and propionates, demonstrated proteolysis at neutral pH-values and a spectrum of antibacterial activity and immunotropic effects determined from the cytokine biosynthesis stimulation (shown ex vivo). As a whole, the origin, properties and effects of the strain allows us to recommend it for trials in human clinic nutrition.
Key words: antibacterial spectrum, cytokines, immunomodulation, model GIT, probiotic effect, probiotic potential, propionates, Propionibacterium freudenreichii RVS-4-irf, proteolytic activity, survival, vitamin B12.
06.11.2015, 1510 просмотров. |
ContactsPostal address: Tel: +7 (495) 315-08-01 Email: editor@genetika.ru |