Preparation of Nanocomplexes of Taunit-Antibiotic Type and Study on their Antifungal Activity against Aspergillus niger and Candida albicans

Автор: A.V. Timofeeva, M.V. Ilyina, E.A. Stepashkina, L.A. Baratova, and G.S. Katrukha

Страница: 18-23

Preparation of Nanocomplexes of Taunit-Antibiotic Type and Study on their Antifungal Activity against Aspergillus niger and Candida albicans

Russian Journal of Biotechnology, 2014, N 3, P. 18-23

UDC 577.181.3

Section:  “Biologicals Technology”

A.V. Timofeeva ^{1, *},  M.V. Ilyina ²,  E.A. Stepashkina ³,  L.A. Baratova ¹,  and  G.S. Katrukha ³

¹  The Belozerskii Research Institute for Physicochemical Biology, Lomonosov Moscow State University,  119991, Moscow Russia

²  The Russian Mendeleev University of Chemical Technology,  125047, Moscow Russia

³  The Gause Institute of Novel Antibiotics, Russ. Acad. Med. Sci.,  119021, Moscow Russia

e-mail:  timofeeva@belozersky.msu.ru

Complexes of widely clinically used polyene antibiotics (amphotericin B, nystatin A1 and natamycin) with a modern Taunit nanoadsorbent were obtained for the first time and their antifugal activities were studied. It was established that the Taunit-nystatin A₁ complex possesses the antifugal activity against Aspergillus niger, whereas the Taunit-natamycin complex is active against Aspergillus niger and Candida albicans. The Taunit-amphotericin B complex failed to exhibit the activity against these test organisms. Possible mechanisms of the obtained complexes functioning are discussed.

Key words:  amphotericin B,  antifungal activity,  Aspergillus niger,  Candida albicans,  carbon nanotubes,  mechanism of action,  multiwalled carbon nanotubes of Taunit type,  natamycin,  nystatin A₁.

19.03.2015, 1855 просмотров.