Riboswitches in regulation of Rho-dependent transcription termination

Sergey Proshkin, Alexander Mironov, Evgeny Nudler

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (Impact Factor: 5.46). 01/2014;

Abstract

Riboswitches are RNA sensors of small metabolites and ions that regulate gene expression in response to environmental changes. In bacteria, the riboswitch sensor domain usually controls the formation of a strong RNA hairpin that either functions as a potent transcription terminator or sequesters a ribosome-binding site. A recent study demonstrated a novel mechanism by which a riboswitch controls Rho-dependent transcription termination. This riboswitch mechanism is likely a widespread mode of gene regulation that determines whether a protein effector is able to attenuate transcription. This article is part of a Special Issue entitled: Riboswitches.

27.04.2014, 2891 просмотр .